Extranodal Metastasis Predicts Poor Survival in Advanced Colorectal

Soichi Tsutsumi, Reina Watanabe, Yuichi Tabe, Takaaki Fujii, Hiroki Morita, Wakako Kigure, Toshihide Kato, Hayato Yamauchi, Makoto Sakai, Takayuki Asao and Hiroyuki Kuwano

DOI 10.5754/hge10139
2012; 59(114):

KEY WORDS: Colorectal Cancer; Extranodal Metastasis; Prognosis.
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ABSTRACT

Background/Aims: The prognostic significance of extranodal metastasis (ENM) in colorectal cancer (CRC) is disregarded by the TNM classification system. The influence of ENM on survival among locally advanced CRC patients was examined. Methodology: We reviewed retrospectively the clinical course of 263 patients who underwent surgical resection of locally advanced CRC at our Department between 2005 and 2009. We analyzed the prognostic factors with special reference to the clinicopathological factors of primary tumors.
Results: Thirty-eight cases of ENM were detected among patients with CRC. Compared with ENMnegative cancers, ENM-positive cancers were associated with poorer tumor differentiation grade (p=0.026) and higher prevalence of TNM-stage (p Conclusions: ENM appears to be a strong independent negative prognostic factor of poor survival in locally advanced CRC.

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Source: https://www.hepato-gastroenterology.org/?p=3888

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